Enhancement of experimental metastatic ability by tumor necrosis factor-alpha alone or in combination with interferon-gamma

✍ Scribed by P. -L. Lollini; C. Giovanni; G. Nicoletti; A. Bontadini; P. -L. Tazzari; L. Landuzzi; K. Scotlandi; P. Nanni

• Publisher: Springer
• Year: 1990
• Tongue: English
• Weight: 482 KB
• Volume: 8
• Category: Article
• ISSN: 0262-0898
• DOI: 10.1007/bf00117794

✦ Synopsis

The effects of recombinant tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) on B16 mouse melanoma experimental metastatic ability and major histocompatibility complex (H-2b) antigens expression were studied. B16 cells exposed in vitro to TNF-alpha had an increased H-2 expression and were more metastatic than untreated cells. The simultaneous treatment with TNF-alpha and IFN-gamma amplified the enhancement of experimental metastasis and all other effects obtained with TNF-alpha alone. The B16 clone B78H1, selectively resistant to H-2 induction and to enhancement of metastatic ability by IFN-gamma, was not affected by treatment with TNF-alpha and with TNF-alpha + IFN-gamma. These findings contribute to a better understanding of the pleiotropic effects of TNF, some of which can have opposing actions in the complex tumor-host relationships.