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Enhancement of cisplatin sensitivity by NSC109268 in budding yeast and human cancer cells is associated with inhibition of S-phase progression

✍ Scribed by Dilip Jain; Nila Patel; Melanie Shelton; Alakananda Basu; Rouel Roque; Wolfram Siede

Publisher
Springer
Year
2010
Tongue
English
Weight
414 KB
Volume
66
Category
Article
ISSN
0344-5704

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## Abstract Cyclin D1 is a well‐known cell cycle regulator. Recently, its pro‐survival function has been revealed in several tumors. Because increasing expression of cyclin D1 is a common event in oral squamous cell carcinoma (OSCC) and has been correlated with cisplatin resistance, we investigated