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Enhancement of cisplatin cytotoxicity by SAHA involves endoplasmic reticulum stress-mediated apoptosis in oral squamous cell carcinoma cells

✍ Scribed by Maiko Suzuki; Manabu Endo; Fumiaki Shinohara; Seishi Echigo; Hidemi Rikiishi


Publisher
Springer
Year
2009
Tongue
English
Weight
403 KB
Volume
64
Category
Article
ISSN
0344-5704

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## Abstract Our study was conducted to investigate whether anticancer drugs, cisplatin (CDDP) and/or 5‐fluorouracil (5‐FU), can modulate Fas‐mediated apoptosis in oral squamous cell carcinoma (OSCC) cell lines. When OSCC cell lines, NA and HSC‐4, were treated with CDDP and/or 5‐FU, Fas and its mRNA