## Abstract Peroxisome proliferator–activated receptor (PPAR) α is a ligand‐activated transcription factor that has been linked with rodent hepatocarcinogenesis. It has been suggested that __PPARα__ mRNA expression levels are an important determinant of rodent hepatic tumorigenicity. Previous work
Enhancement of BRCA1 gene expression by the peroxisome proliferator-activated receptor γ in the MCF-7 breast cancer cell line
✍ Scribed by Pignatelli, Miguel; Cocca, Claudia; Santos, Angel; Perez-Castillo, Ana
- Book ID
- 110067910
- Publisher
- Nature Publishing Group
- Year
- 2003
- Tongue
- English
- Weight
- 187 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0950-9232
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Using clonal cell cultures, a significant increase in chromosomal aberrations (aneuplolidy, dicentrics and chromatid breaks) were observed in MCF‐7 cells compared with HeLa. BRCA1 expression was lower in MCF‐7 cells than in HeLa cells. Since BRCA1 is known to play a role in the maintenance of chromo
## Abstract Peroxisome‐proliferator activated receptor‐gamma (PPARγ) belongs to a family of nuclear receptors and acts as receptor for peroxisome‐proliferators, steroids, retinoic acids, and polyunsaturated fatty acids. Our study examined the transcript levels of peroxisome‐proliferator activated r