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Enhanced uptake of specific antigen by epithelial cells in sensitized mice: Role of IL-4, IgE and CD23

✍ Scribed by Yu, Linda C.; Yang, Ping-Chang; Berin, M. Cecilia; Conrad, Daniel H.; Perdue, Mary H.

Book ID: 123034024
Publisher: Elsevier Science
Year: 2000
Tongue: English
Weight: 170 KB
Volume: 118
Category: Article
ISSN: 0016-5085
DOI: 10.1016/S0016-5085(00)81384-0

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IL-4 specifically induced IgE production by peripheral blood lymphocytes or by tonsil or spleen cells from healthy donors. IL-4-induced IgE synthesis was dependent on CD4+ T cells and monocytes and was blocked by IFN-y, IFN-a, and prostaglandin E-2 (PGE-2). These substances also inhibited IL4-induce