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Enhanced transport of a novel anti-HIV agent—cosalane and its congeners across human intestinal epithelial (Caco-2) cell monolayers

✍ Scribed by Chandrasekhar Udata; Jignesh Patel; Dhananjay Pal; Elzbieta Hejchman; Mark Cushman; Ashim K Mitra


Book ID
108454177
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
226 KB
Volume
250
Category
Article
ISSN
0378-5173

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Transport of cosalane—a highly lipophili
✍ Dhananjay Pal; Chandrasekhar Udata; Ashim K. Mitra 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 203 KB 👁 1 views

Cosalane is a potent inhibitor of HIV replication with activity against a broad range of viral targets. However, the oral bioavailability of this highly lipophilic compound is extremely poor (<1%). Also, cosalane accumulates in high concentration in the liver after intravenous administration, with c