✦ LIBER ✦

Enhanced theophylline metabolism in patients with bronchial asthma at age 4 and under

✍ Scribed by Junko Kizu; Motoki Arakawa; Yoshihiro Arakawa; Fusako Komoda; Masaru Takamizawa; Tsutomu Iwata; Tetsuo Hayakawa; Kazuhiro Imai

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 69 KB
Volume: 13
Category: Article
ISSN: 0269-3879
DOI: 10.1002/(sici)1099-0801(199911)13:7<462::aid-bmc912>3.0.co;2-p

No coin nor oath required. For personal study only.

✦ Synopsis

The plasma levels of theophylline (TP) and its metabolites were measured in patients with bronchial asthma who were treated with a slow-release preparation of TP. The ratios of the plasma levels of these metabolites to TP levels in the group aged 1-4 years were larger than those in the group aged 5 years and older, suggesting enhanced activity of drug-metabolizing enzymes during infancy.