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Enhanced Synaptic Potentiation in Transgenic Mice Expressing presenilin 1 Familial Alzheimer's Disease Mutation Is Normalized with a Benzodiazepine

✍ Scribed by Shahid H. Zaman; Angèle Parent; Aaron Laskey; Michael K. Lee; David R. Borchelt; Sangram S. Sisodia; Roberto Malinow


Book ID
115641506
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
245 KB
Volume
7
Category
Article
ISSN
0969-9961

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Mutations in the presenilin-1 (PS1) gene account for the majority of familial early-onset Alzheimer's disease (EOAD) cases. We screened the coding part of the PS1 gene for the presence of mutations in a French family with EOAD, using single strand conformation polymorphism (SSCP) analysis. Patients