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Enhanced solubility and dissolution of simvastatin by HPMC-based solid dispersions prepared by hot melt extrusion and spray-drying method

✍ Scribed by Javeer, Sharadchandra Dagadu; Patole, Rahul; Amin, Purnima


Book ID
121598535
Publisher
Springer Netherlands
Year
2013
Tongue
English
Weight
527 KB
Volume
43
Category
Article
ISSN
2093-5552

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Nimodipine (NM) solid dispersions (SD) were prepared by hot-melt extrusion with polyvinylpyrrolidone/vinyl acetate copolymer (PVP-VA; Kollidon VA64) as the carrier, then the extrudate was stored at different temperatures (20Β°C, 40Β°C, 60Β°C) after milling. Conventional differential scanning calorimetr