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Enhanced ROS Production in Oncogenically Transformed Cells Potentiates c-Jun N-Terminal Kinase and p38 Mitogen-Activated Protein Kinase Activation and Sensitization to Genotoxic Stress

✍ Scribed by Benhar, M.; Dalyot, I.; Engelberg, D.; Levitzki, A.


Book ID
126597773
Publisher
American Society for Microbiology
Year
2001
Tongue
English
Weight
844 KB
Volume
21
Category
Article
ISSN
0270-7306

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Recently identified c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase are activated by stimuli of various cellular stresses, cytokines, and growth factors. Strong activation of JNK was reported in the regenerating liver, implicating JNK in growth stimulation of hepatocytes. Howe