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Enhanced response to radiotherapy in tumours deficient in the function of hypoxia-inducible factor-1

✍ Scribed by Kaye J. Williams; Brian A. Telfer; Dia Xenaki; Mary R. Sheridan; Isabelle Desbaillets; Hans J.W. Peters; Davina Honess; Adrian L. Harris; Gabi U. Dachs; Albert van der Kogel; Ian J. Stratford

Book ID
118496432
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
184 KB
Volume
75
Category
Article
ISSN
0167-8140

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## Abstract Sleep‐disordered breathing with recurrent apnea is associated with intermittent hypoxia (IH). Cardiovascular morbidities caused by IH are triggered by increased generation of reactive oxygen species (ROS) by pro‐oxidant enzymes, especially NADPH oxidase‐2 (Nox2). Previous studies showed