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Enhanced replication and pathogenesis of Moloney murine leukemia virus in mice defective in the murine APOBEC3 gene

✍ Scribed by Audrey Low; Chioma M. Okeoma; Nika Lovsin; Marcelo de las Heras; Thomas H. Taylor; B. Matija Peterlin; Susan R. Ross; Hung Fan

Book ID
113947723
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
888 KB
Volume
385
Category
Article
ISSN
0042-6822

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A panel of recombinant virus genomes was constructed by exchanging homologous genome fragments between the potent T-cell lymphoma inducer Moloney murine leukemia virus (MoMuLV) and its closely related but significantly less virulent relative MoMuLV-TB. Testing of these recombinant viruses in BALB/c