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Enhanced recombinant human erythropoietin production by Pichia pastoris in methanol fed-batch/sorbitol batch fermentation through pH optimization

✍ Scribed by Elif Şükran Soyaslan; Pınar Çalık

Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
354 KB
Volume
55
Category
Article
ISSN
1369-703X

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## Abstract **BACKGROUND:** The influence of methanol feed rate on recombinant human growth hormone (rhGH) production by __Pichia pastoris__ hGH‐Mut^+^ in medium containing sorbitol was investigated at three different specific growth rates (µ), namely, 0.02 (MS‐0.02), 0.03 (MS‐0.03), and 0.04 (MS‐0