Enhanced Pulmonary Expression of CXC Chemokines during Hepatic Ischemia/Reperfusion-Induced Lung Injury in Mice

The ratio of ELR+ to ELR− CXC chemokines

The ratio of ELR+ to ELR− CXC chemokines affects the lung and liver injury following hepatic ischemia/reperfusion in the rat

✍ Lisa M. Colletti; Maranne E. Green; Marie D. Burdick; Robert M. Strieter 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 403 KB 👁 1 views

Hepatic ischemia/reperfusion (I/R) results in a neutrophildependent lung and liver injury. The process of neutrophil recruitment and activation in this injury is at least partially dependent on the presence of the ELR؉ CXC chemokines. Other investigations have shown that ELR؊ CXC chemokines can bloc