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Enhanced production of human Cytochrome P450 2C9 byEscherichia

✍ Scribed by Da C. Hao; Pan H. Zhu; Sheng L. Yang; Ling Yang


Publisher
Springer
Year
2006
Tongue
English
Weight
360 KB
Volume
23
Category
Article
ISSN
1573-0972

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Cytochrome P450 2C9 (CYP2C9) expression is regulated by multiple nuclear receptors including the constitutive androstane receptor (CAR) and pregnane X receptor (PXR). We compared coregulation of CYP2C9 with CYP2B6 and CYP3A4, prototypical target genes for human CAR and PXR using human hepatocyte cul