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Enhanced neuronal damage by co-administration of quinolinic acid and free radicals, and protection by adenosine A2A receptor antagonists

✍ Scribed by W M H Behan; T W Stone

Book ID
110007202
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
272 KB
Volume
135
Category
Article
ISSN
0007-1188

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Interleukin-1Ξ² but not tumor necrosis factor-Ξ± potentiates neuronal damage by quinolinic acid: Protection by an adenosine A2A receptor antagonist
✍ Trevor W. Stone; Wilhelmina M.H. Behan πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 652 KB

## Abstract Quinolinic acid is an agonist at glutamate receptors sensitive to N‐methyl‐D‐aspartate (NMDA). It has been implicated in neural dysfunction associated with infections, trauma, and ischemia, although its neurotoxic potency is relatively low. This study was designed to examine the effects