A method for the one-pot regioselective
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Alan Cuthbertson; Bård Indrevoll
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Article
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2000
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Elsevier Science
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French
⚖ 78 KB
A one-pot method for the regioselective formation of the disulfide bridges of α-conotoxin SI employing temperature-controlled orthogonal protecting groups is reported. The pairing of t-butyl and 4-methylbenzyl sidechain protecting groups was chosen for the four cysteine residues. Cleavage of the pep