Enhanced MHC class II-restricted presentation of measles virus (MV) hemagglutinin in transgenic mice expressing human MV receptor CD46

Efficient MHC Class II-restricted presen

Efficient MHC Class II-restricted presentation of measles virus to T cells relies on its targeting to its cellular receptor human CD46 and involves an endosomal pathway

✍ D. Gerlier; M.-C. Trescol-Biémont; G. Varior-Krishnan; D. Naniche; I. Fugier-Viv 📂 Article 📅 1994 🏛 Elsevier Science 🌐 English ⚖ 297 KB

## ABSTRACT The role of the measles virus (MV) receptor, human CD46, in the uptake of MV and antigen presentation by Major Histocompatibility Complex (MHC) class II molecules was investigated. Expression of CD46 in murine B cells resulted in cells highly efficient in capturing UV‐inactivated MV par