Enhanced matrix synthesis and in vitro formation of cartilage-like tissue by genetically modified chondrocytes expressing BMP-7

Toll-like receptors and chondrocytes: Th

Toll-like receptors and chondrocytes: The lipopolysaccharide-induced decrease in cartilage matrix synthesis is dependent on the presence of toll-like receptor 4 and antagonized by bone morphogenetic protein 7

✍ K. Bobacz; I. G. Sunk; J. G. Hofstaetter; L. Amoyo; C. D. Toma; S. Akira; T. Wei 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 586 KB

## Abstract ## Objective To assess the presence of Toll‐like receptors (TLRs) 1–9 in human articular cartilage, and to investigate the effects of lipopolysaccharide (LPS)–induced activation of TLR‐4 on biosynthetic activity and matrix production by human articular chondrocytes. ## Methods TLRs 1