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Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells

โœ Scribed by Paul Kievit; Jane K. Howard; Michael K. Badman; Nina Balthasar; Roberto Coppari; Hiroyuki Mori; Charlotte E. Lee; Joel K. Elmquist; Akihiko Yoshimura; Jeffrey S. Flier


Book ID
116372482
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
549 KB
Volume
4
Category
Article
ISSN
1550-4131

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Obesity is associated with chronic inflammation and contributes to the development of insulin resistance and nonalcoholic fatty liver disease. The suppressor of cytokine signaling-3 (SOCS3) protein is increased in inflammation and is thought to contribute to the pathogenesis of insulin resistance by