Enhanced intracellular delivery and improved antitumor efficacy of doxorubicin by sterically stabilized liposomes modified with a synthetic RGD mimetic

Intracellular delivery of doxorubicin wi

Intracellular delivery of doxorubicin with RGD-modified sterically stabilized liposomes for an improved antitumor efficacy: In vitro and in vivo

✍ Xiao-Bing Xiong; Yue Huang; Wan-Liang LU; Xuan Zhang; Hua Zhang; Tsuneji Nagai; 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 333 KB

Passive targeting by sterically stabilized liposomes (SSL), once combined with efficient intracellular delivery, may be a very useful strategy to improve the antitumor efficacy for the anticancer agents. The arginine-glycine-aspartic acid tripeptide (RGD) is known to serve as a recognition motif for