Prediction of in vivo intestinal absorpt
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Manthena V.S. Varma; Ramesh Panchagnula
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Article
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2005
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John Wiley and Sons
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English
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The purpose of this study is to determine the functional role of P-glycoprotein (P-gp) in intestinal absorption of drugs and to quantitatively predict the in vivo absorption enhancement on P-gp inhibition. In situ single-pass rat ileum permeability and aqueous solubility were measured for a set of 1