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Enhanced inhibition of tissue factor by the extended form of an endothelial cell glycoprotein (an extrinsic pathway inhibitor)

✍ Scribed by P. Colburn; J. W. Crabb; V. Buonassisi

Publisher: John Wiley and Sons
Year: 1991
Tongue: English
Weight: 815 KB
Volume: 148
Category: Article
ISSN: 0021-9541
DOI: 10.1002/jcp.1041480219

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✦ Synopsis

We have identified, in the supernatant medium of cultured endothelial cells, an additional inhibitor of tissue factor that is eluted at higher salt concentrations during heparin-Sepharose chromatography and is a much more potent inhibitor of the activation of the coagulation cascade than the species we studied earlier (Colburn and Buonassisi: In Vitro Cellular and Developmental Biology 24:l 133-11 36, 1988). The inhibitor we described earlier has been shown to be functionally

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Factor J (FJ) is a protein present in human serum, with inhibitory activity against C1. Here we describe the quantitation of FJ in human serum by means of an ELISA inhibition assay. We have purified FJ from the urine of a normal donor following a previously published method with slight modifications