Enhanced inflammatory responses of chronic granulomatous disease leukocytes involve ROS-independent activation of NF-κB

The G-Protein-coupled bile acid receptor

The G-Protein-coupled bile acid receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing nuclear factor kappa light-chain enhancer of activated B cells (NF-κB) in mice

✍ Yan-Dong Wang; Wei-Dong Chen; Donna Yu; Barry M. Forman; Wendong Huang 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 934 KB

Gpbar1 (TGR5), a membrane-bound bile acid receptor, is well known for its roles in regulation of energy homeostasis and glucose metabolism. TGR5 also displays strong attenuation of macrophage reactivity in vitro, but the physiological roles of TGR5 in inflammatory response, and its mechanism, is unk