Enhanced in vivo Magnetic Resonance Imaging of Tumors by PEGylated Iron-Oxide–Gold Core–Shell Nanoparticles with Prolonged Blood Circulation Properties
✍ Scribed by Michiaki Kumagai; Tridib Kumar Sarma; Horacio Cabral; Sachiko Kaida; Masaki Sekino; Nicholas Herlambang; Kensuke Osada; Mitsunobu R. Kano; Nobuhiro Nishiyama; Kazunori Kataoka
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 580 KB
- Volume
- 31
- Category
- Article
- ISSN
- 1022-1336
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✦ Synopsis
Abstract
High‐density poly(ethylene glycol) (PEG)‐coated iron‐oxide–gold core–shell nanoparticles (AuIONs) were developed as T~2~‐weighted magnetic resonance imaging (MRI) contrast agents for cancer imaging. The PEG‐coated iron‐oxide–gold core–shell nanoparticles (PEG‐AuIONs) were approximately 25 nm in diameter with a narrow distribution. Biodistribution experiments in mice bearing a subcutaneous colon cancer model prepared with C26 murine colon adenocarcinoma cells showed high accumulation of the PEG‐AuIONs within the tumor mass and low nonspecific accumulation in the liver and spleen, resulting in high specificity to solid tumors. T~2~‐weighted MR images following intravenous injection of PEG‐AuIONs showed selective negative enhancement of tumor tissue in an orthotopic pancreatic cancer model prepared with MiaPaCa‐2 human pancreatic adenocarcinoma cells. These results indicate that PEG‐AuIONs are a promising MRI contrast agent for diagnosis of malignant tumors, including pancreatic cancer.
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