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Enhanced immunogenicity of MHC class I-restricted tumor-associated altered peptide ligands

✍ Scribed by Hannes Uchtenhagen; Evi Stahl; Adil Doganay Duru; Esam Tolba; Patrick Celie; Sebastian Springer; Thorbald van Hall; Ton N. Schumacher; Adnane Achour

Book ID: 113805777
Publisher: Elsevier Science
Year: 2012
Tongue: English
Weight: 64 KB
Volume: 51
Category: Article
ISSN: 0161-5890
DOI: 10.1016/j.molimm.2012.02.095

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Strategies to identify tumor-associated antigens rely on the paradigm that tumor-associated peptides presented in the context of HLA-class I are recognized by the cellular immune system. Approaches to isolate tumor-specific cytotoxic T lymphocytes (CTL) from tumor-infiltrating lymphocytes are diffic