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Enhanced IL-1β-induced IL-8 production in cystic fibrosis lung epithelial cells is dependent of both mitogen-activated protein kinases and NF-κB signaling

✍ Scribed by Céline Muselet-Charlier; Telma Roque; Emilie Boncoeur; Katarina Chadelat; Annick Clement; Jacky Jacquot; Olivier Tabary

Book ID: 116294732
Publisher: Elsevier Science
Year: 2007
Tongue: English
Weight: 334 KB
Volume: 357
Category: Article
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2007.03.141

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## Abstract We have shown that the bacterial iron chelator, deferoxamine (DFO), triggers inflammatory signals including the production of CXC chemokine IL‐8, in human intestinal epithelial cells (IECs) by activating the ERK1/2 and p38 kinase pathways. In this study we investigated the mechanisms in