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Enhanced identification of lethal yellow (Ay/Ay) mouse embryos by means of delayed development of four-cell stages

✍ Scribed by Granholm, Nels H. ;Johnson, Phyllis M.

Publisher: John Wiley and Sons
Year: 1978
Tongue: English
Weight: 302 KB
Volume: 205
Category: Article
ISSN: 0022-104X
DOI: 10.1002/jez.1402050218

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✦ Synopsis

Abstract

At present, experimental studies on the primary genetic lesion in A^y^/A^y^ embryos are restricted by the absence of techniques designed to identify A^y^ homozygotes prior to the onset of secondary defects. This paper describes a methodology to enrich the yields of A^y^ homozygotes in experimental populations by taking advantage of an early homozygous A^y^ expression‐lagging development in 4‐cell embryos.

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