Induction of sensitivity to ganciclovir
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Cheng Qian; Roberto Bilbao; Oscar Bruña; Jesús Prieto
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Article
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1995
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John Wiley and Sons
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English
⚖ 694 KB
We have analyzed the ability of a recombinant replication-defective adenovirus to transfer the thymidine kinase gene of herpes simplex virus (HSV-tk) into hepatocellular carcinoma (HCC) cells to confer sensitivity to ganciclovir. Three HCC cell lines (Hep3B, PLC/PRF/5, and HepG2) were efficiently in