Enhanced growth of primary moloney virus-induced sarcomas in mice

✍ Scribed by George E. Pierce

• Publisher: John Wiley and Sons
• Year: 1971
• Tongue: French
• Weight: 675 KB
• Volume: 8
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910080104

✦ Synopsis

Abstract

Pre‐treatment of BALB/c mice with an intraperitoneal injection of heat‐inactivated serum obtained from BALB/c mice with progressively growing Moloney‐virus‐induced sarcomas (“progressor” mice) shortens the latent period and increases the growth rate and maximum size of primary sarcomas induced in these mice by Moloney virus inoculation 24 h after the serum injection.

Pre‐treatment with heat‐inactivated serum obtained from BALB/c mice after the complete regression of Moloney sarcomas (“regressor” mice) decreases the growth of subsequently induced Moloney sarcomas in mice so treated.

These observations are discussed in relation to the recent findings of Hellström and Hellström (1969, 1970) that serum fiom “progressor” mice blocks the cytotoxic effects of specifically immune lymph‐node cells when tested against target Moloney sarcoma cells in vitro arid that serum from “regressor” mice competes with or abrogates the blocking effect of “progressor” serum.