Enhanced expression of type I interferon and toll-like receptor-3 in primary biliary cirrhosis
✍ Scribed by Takii, Yasushi; Nakamura, Minoru; Ito, Masahiro; Yokoyama, Terufumi; Komori, Atsumasa; Shimizu-Yoshida, Yuki; Nakao, Rumiko; Kusumoto, Koichiro; Nagaoka, Shinya; Yano, Koji
- Book ID
- 109885914
- Publisher
- Nature Publishing Group
- Year
- 2005
- Tongue
- English
- Weight
- 420 KB
- Volume
- 85
- Category
- Article
- ISSN
- 0023-6837
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## Abstract Toll‐like receptor 3 (TLR3) recognizes double‐stranded RNA and induces type I interferon (IFN)‐mediated antiviral immunity against a number of viral infections. Type III IFN (IFN‐λ) is a newly identified antiviral cytokine that has biological functions similar to those of type I IFNs. W
## Abstract ## Objective To investigate the production of type I interferon (IFN) by myoblasts and to identify its cell source and the link to Toll‐like receptor (TLR) and C‐type lectin receptor (CLR) expression and function in myositis biopsy sections. ## Methods Production of IFNβ was assessed