✦ LIBER ✦

Enhanced epidermal growth factor receptor synthesis in human squamous carcinoma cells exposed to low levels of oxygen

✍ Scribed by Keith R. Laderoute; Tandora D. Grant; Brian J. Murphy; R. M. Sutherland

Publisher: John Wiley and Sons
Year: 1992
Tongue: French
Weight: 825 KB
Volume: 52
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910520317

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✦ Synopsis

Exposure of human A43 I squamous carcinoma cells to levels of hypoxia found in some solid tumors causes 2-fold increases in epidermal growth-factor receptor (EGF-R) mRNA levels and rate of receptor protein synthesis compared with aerobic cells. Similar results are shown for receptor message from other squamous carcinoma cells, human keratinocytes, and human W138 fibroblasts. Less basal tyrosine phosphorylation of the receptor occurs in hypoxic compared with aerobic A43 I cells. Scatchard analysis also shows that reoxygenated A43 I cells display enhanced surface expression of the EGF-R compared with aerobic control cells. Possible mechanisms and implications for tumor therapy are discussed.

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