Enhanced elimination of piroxicam by administration of activated charcoal or cholestyramine

✍ Scribed by D. G. Ferry; L. R. Gazeley; W. J. Busby; D. M. G. Beasley; I. R. Edwards; A. J. Campbell

• Book ID: 104719527
• Publisher: Springer
• Year: 1990
• Tongue: English
• Weight: 239 KB
• Volume: 39
• Category: Article
• ISSN: 0031-6970
• DOI: 10.1007/bf00316105

✦ Synopsis

This study has compared the effect of repeated administration of charcoal and cholestyramine on the elimination of piroxicam. Eight young adults were given piroxicam as a single dose of 20 mg, on 3 separate occasions. On one of the occasions charcoal was also given. On another occasion cholestyramine was also administered. The mean elimination half-life after piroxicam alone was 53.1 h. This was reduced to 40.0 h by charcoal administration and to 29.6 h after administration of cholestyramine. In the second phase of the study 7 elderly subjects received piroxicam 20 mg for 14 days on two occasions. Cholestyramine administration at the end of one of the periods reduced the mean elimination half-life of piroxicam from 52.3 h to 27.3 h.