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Enhanced Efficiency of Thiourea Catalysts by External Brønsted Acids in the Friedel–Crafts Alkylation of Indoles

✍ Scribed by Eugenia Marqués-López; Ana Alcaine; Tomás Tejero; Raquel P. Herrera


Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
236 KB
Volume
2011
Category
Article
ISSN
1434-193X

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## Abstract A new enantioselective Brønsted acid‐catalyzed Friedel–Crafts reaction of indole with cyclic imines has been develeoped. This organocatalytic reaction provides for the first time optically active indolindolinone derivatives in high yields and with excellent enantioselectivities (up to 9