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Enhanced efficacy of gemcitabine in combination with anti-CD20 monoclonal antibody against CD20+ non-Hodgkin's lymphoma cell linesin vitroand inscidmice

✍ Scribed by Mitchell R Smith; Indira Joshi; Fang Jin; Coleman Obasaju


Book ID
115010623
Publisher
BioMed Central
Year
2005
Tongue
English
Weight
554 KB
Volume
5
Category
Article
ISSN
1471-2407

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Rituximab is a chimeric anti CD-20 monoclonal antibody containing human IgG1 kappa constant regions, with murine variable regions. The anti-lymphoma effects of Rituximab are probably due to complement and antibody-dependent cell-mediated cytotoxicity, and induction of apoptosis. Phase II trials have