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Enhanced dissolution and oral bioavailability of α-tocopheryl esters by dimethyl-β-cyclodextrin complexation

✍ Scribed by Kaneto Uekama; Yasuhide Horiuchi; Masahiko Kikuchi; Fumitoshi Hirayama; Takanori Ijitsu; Masao Ueno

Book ID
104872075
Publisher
Springer Netherlands
Year
1988
Tongue
English
Weight
367 KB
Volume
6
Category
Article
ISSN
0923-0750

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✍ P. Corvi Mora; M. Cirri; B. Allolio; F. Carli; P. Mura 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 161 KB

In the present work we investigated the possibility of improving dehydroepiandrosterone (DHEA) solubility and bioavailability by high-energy cogrinding with alpha-cyclodextrin (alpha-Cd) in the presence or absence of different auxiliary substances (glycine, biomaltodextrin, poly(vinyl pyrrolidone),