✦ LIBER ✦

Enhanced Conformational Sampling of M2 Muscarinic Acetylcholine Receptor for Designing Selective Allosteric Drugs

✍ Scribed by Miao, Yinglong; McCammon, J. Andrew

Book ID: 122262704
Publisher: Biophysical Society
Year: 2013
Tongue: English
Weight: 42 KB
Volume: 104
Category: Article
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2012.11.182

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Activation of the M2 Muscarinic Receptor

Activation of the M2 Muscarinic Receptor and Computer-Aided Design of Receptor-Selective Allosteric Drugs

✍ Miao, Yinglong; McCammon, J. Andrew 📂 Article 📅 2014 🏛 Biophysical Society 🌐 English ⚖ 45 KB

Antipsychotic Drug-Like Effects of the S

Antipsychotic Drug-Like Effects of the Selective M4 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator VU0152100

✍ Byun, Nellie E; Grannan, Michael; Bubser, Michael; Barry, Robert L; Thompson, An 📂 Article 📅 2014 🏛 Nature Publishing Group 🌐 English ⚖ 1012 KB

The relative selectivity of anticholiner

The relative selectivity of anticholinergic drugs for the M1 and M2 muscarinic receptor subtypes

✍ Dr. Robert E. Burke 📂 Article 📅 1986 🏛 John Wiley and Sons 🌐 English ⚖ 775 KB

Anticholinergic drugs are used to treat a number of neurologic disorders, inctuding parkinsonism, vestibular disturbances, and dystonia. Traditionally, these drugs have been thought to act in similar fashion, as competitive antagonists at a single class of muscarink receptors, and not to differ sign

An investigation of whether agonist-sele

An investigation of whether agonist-selective receptor conformations occur with respect to M2 and M4 muscarinic acetylcholine receptor signalling via Gi/o and Gs proteins

✍ Rajendra Mistry; Mark R Dowling; R A John Challiss 📂 Article 📅 2005 🏛 Nature Publishing Group 🌐 English ⚖ 230 KB

Allosteric site in M2acetylcholine recep

Allosteric site in M2acetylcholine receptors: evidence for a major conformational change upon binding of an orthosteric agonist instead of an antagonist

✍ Maren Großmüller; Johannes Antony; Christian Tränkle; Ulrike Holzgrabe; Klaus Mo 📂 Article 📅 2005 🏛 Springer-Verlag 🌐 English ⚖ 229 KB

Reverse Engineering of the Selective Ago

Reverse Engineering of the Selective Agonist TBPB Unveils Both Orthosteric and Allosteric Modes of Action at the M1 Muscarinic Acetylcholine Receptor

✍ Keov, P.; Valant, C.; Devine, S. M.; Lane, J. R.; Scammells, P. J.; Sexton, P. M 📂 Article 📅 2013 🏛 American Society for Pharmacology and Experimental 🌐 English ⚖ 422 KB