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Enhanced CCL26 production by IL-4 through IFN-γ-induced upregulation of type 1 IL-4 receptor in keratinocytes

✍ Scribed by Natsuko Nishi; Shuichi Yamamoto; Weilin Ou; Eriko Muro; Yukiko Inada; Yuhei Hamasaki


Book ID
116297375
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
371 KB
Volume
376
Category
Article
ISSN
0006-291X

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IL-4 specifically induced IgE production by peripheral blood lymphocytes or by tonsil or spleen cells from healthy donors. IL-4-induced IgE synthesis was dependent on CD4+ T cells and monocytes and was blocked by IFN-y, IFN-a, and prostaglandin E-2 (PGE-2). These substances also inhibited IL4-induce