Enhanced blockade of 45Ca2+ uptake into platelets in manic patients with bipolar affective disorder with flunarazine and verapamil
✍ Scribed by Michael Berk; Nicola Helen Kirchmann
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 458 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0885-6222
No coin nor oath required. For personal study only.
✦ Synopsis
This study examined bipolar patients in the manic and depressed phases of bipolar disorder and controls, measuring basal radiolabelled 45Ca2+ uptake into platelets, and the effects of verapamil and flunarazine on uptake. Radiolabelled 45Ca2f uptake into platelets was measured in the manic ( N = 13) and depressed ( N = 15) phases of bipolar disorder compared to controls ( N = 13) using a p liquid scintillation counter. Both flunarazine ( p = 0.0196) and verapamil ( p = 0.0486) caused greater inhibition of 45Caz+ uptake in manics than controls. Flunarazine ( p = 0,0209) was also associated with greater inhibition of calcium uptake in manics than depressives. Flunarazine and veraparnil enhance the blockade of 45Ca'+ uptake into platelets in manic patients with Bipolar Affective Disorder