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Enhanced Biocompatibility in Biostable Poly(carbonate)urethane

✍ Scribed by Shan-hui Hsu; Yu-Chih Kao; Zu-Chang Lin

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
227 KB
Volume
4
Category
Article
ISSN
1616-5187

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✦ Synopsis

Abstract

Summary: In this work, we synthesized two MDI‐based polyurethanes, including a poly(ether)urethane (PEU) and a poly(carbonate)urethane (PCU), by using different soft segments, poly(tetramethylene oxide) and poly(hexyl, ethyl)carbonate diol ($\overline M$ ∼ 2 000). We demonstrated that, in addition to the enhanced biostability of PCU over PEU, the biological performances of PCU in vitro were also improved in general. These included, better cellular attachment and proliferation, less platelet activation, as well as reduced monocyte activation. The unusual wide‐ranging enhancement in biocompatibility for PCU was believed to be related to the larger micro‐phase separation in PCU (∼25 nm) that caused distinct protein adsorption on the surface.

The total number of adherent monocytes (nonactivated and activated) on the bare sample surfaces, albumin pre‐adsorbed sample surfaces, and fibrinogen pre‐adsorbed sample surfaces.

imageThe total number of adherent monocytes (nonactivated and activated) on the bare sample surfaces, albumin pre‐adsorbed sample surfaces, and fibrinogen pre‐adsorbed sample surfaces.

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