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Enhanced bioavailability of poorly water-soluble clotrimazole by inclusion with β-cyclodextrin

✍ Scribed by Balakrishnan Prabagar; Bong-Kyu Yoo; Jong-Soo Woo; Jung-Ae Kim; Jong-Dai Rhee; Ming Guan Piao; Han-Gon Choi; Chul Soon Yong


Publisher
Springer
Year
2007
Tongue
English
Weight
507 KB
Volume
30
Category
Article
ISSN
0253-6269

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In the present work we investigated the possibility of improving dehydroepiandrosterone (DHEA) solubility and bioavailability by high-energy cogrinding with alpha-cyclodextrin (alpha-Cd) in the presence or absence of different auxiliary substances (glycine, biomaltodextrin, poly(vinyl pyrrolidone),