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Enhanced Bioavailability of a Poorly Soluble VR1 Antagonist Using an Amorphous Solid Dispersion Approach: A Case Study

โœ Scribed by Kennedy, Michael; Hu, Jack; Gao, Ping; Li, Lan; Ali-Reynolds, Alana; Chal, Ben; Gupta, Vicki; Ma, Chandra; Mahajan, Nidhi; Akrami, Anna; Surapaneni, Sekhar

Book ID
118061651
Publisher
American Chemical Society
Year
2008
Tongue
English
Weight
309 KB
Volume
5
Category
Article
ISSN
1543-8384

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A solid-state approach to enable early d
A solid-state approach to enable early development compounds: Selection and animal bioavailability studies of an itraconazole amorphous solid dispersion
โœ David Engers; Jing Teng; Jonathan Jimenez-Novoa; Philip Gent; Stuart Hossack; Ch ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 436 KB

A solid-state approach to enable compounds in preclinical development is used by identifying an amorphous solid dispersion in a simple formulation to increase bioavailability. Itraconazole (ITZ) was chosen as a model crystalline compound displaying poor aqueous solubility and low bioavailability. So