Enhanced Axonal Regeneration Following Combined Demyelination plus Schwann Cell Transplantation Therapy in the Injured Adult Spinal Cord

A combination of insulin-like growth fac

A combination of insulin-like growth factor-I and platelet-derived growth factor enhances myelination but diminishes axonal regeneration into Schwann cell grafts in the adult rat spinal cord

✍ Martin Oudega; Xiao Ming Xu; Véronique Guénard; Naomi Kleitman; Mary Bartlett Bu 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 290 KB 👁 1 views

Insulin-like growth factor-I (IGF-I) promotes axonal regeneration in the peripheral nervous system and this effect is enhanced by platelet-derived growth factor (PDGF). We decided, therefore, to study the effects of these factors on axonal regeneration in the adult rat spinal cord. Semipermeable pol