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Enhanced apoptosis in prolonged cultures of senescent porcine pulmonary artery endothelial cells

โœ Scribed by Jianliang Zhang; Jawaharlal M Patel; Edward R Block

Book ID
114096186
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
366 KB
Volume
123
Category
Article
ISSN
0047-6374

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Exposure to hypoxia (0% O2) for 4-24 h resulted in increased intracellular L-arginine content and increased activity of calpain, a calcium-dependent neutral cysteine protease, in pulmonary artery endothelial cells. Calpain-inhibitor I abolished the increased L-arginine content in hypoxic cells. When