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Enhanced antitumor activity of irofulven in combination with gemcitabine against the MV522 human lung carcinoma xenograft


Book ID
117659426
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
265 KB
Volume
38
Category
Article
ISSN
0959-8049

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## Abstract ## BACKGROUND: It has been demonstrated that NK012, a novel 7โ€ethylโ€10โ€hydroxycamptothecin (SNโ€38)โ€incorporating polymeric micelle, exerts significantly more potent antitumor activity against various human tumor xenografts than irinotecan (CPTโ€11) (a waterโ€soluble prodrug of SNโ€38). Co