Enhanced Antibody-Dependent Lymphocyte-Mediated Cytotoxic activity in mice cured from an ascitic tumor by a single tumor aspiration
✍ Scribed by M. H. Claësson; L. Olsson
- Book ID
- 104660555
- Publisher
- Springer-Verlag
- Year
- 1977
- Tongue
- English
- Weight
- 331 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0340-7004
No coin nor oath required. For personal study only.
✦ Synopsis
Aspiration of approximately 50% of the tumor volume in the syngenie lethal C3H-L1 ascites tumor system at day 12 after intraperitoneal injection of 2 x 107 tumor cells cured about 40% of the animals from the ascites tumor. The recovering mice showed strong immunity to a second challenge with tumor cells and transfer of spleen cells from recovering mice protected normal mice to tumor development. Complementdependent serum-mediated cytotoxicity (CDSC) against tumor cells in vitro appeared both in non-recovering and recovering mice being most pronounced in completely cured animals. Antibody-dependent, lymphocyte-mediated cytotoxicity (ADLC) was absent in tumor-bearing and dying mice but appeared early after recovery in cured mice. No direct lymphocyte-mediated cytotoxicity (DLC) couM be demonstrated either in non-recovering or in recovering mice.