Enhanced amperometric detector for local anesthetics in liquid chromatography with metal-oxide dispersed glassy carbon electrodes
✍ Scribed by Jianxun Zhou; Lijing Zhang; Erkang Wang
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 531 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1040-0397
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✦ Synopsis
Chemically modified electrodes (CMEs) prepared by the dispersion of metal oxide particles on a glassy carbon (GC) substrate greatly enhance the voltammetric response and amperometric detection of local anesthetics following liquid chromatography (LC). The enhancement is more pronounced with the GC electrodes dispersed by the metal oxides of higher oxidation states ( + 3 , +4) and for the species exhibiting relatively slow electrode kinetics under given conditions. With an applied potential of 1.2 V (vs. SCE), LC amperometric detection of the analytes at the a-alumina modified GC surface gives detection limits 2-5 times lower than those obtained at the bare electrode. The metal oxide-dispersed electrodes display significant improvemenr in sensitivity, and selectivity and indicate excellent preparation reproducibility and performance stability.