Whereas the importance of the Fas/FasL system in the regulation of T-cell homeostasis is well established, it is not yet clear if FasL is involved in B-cell regulation, especially in the clonal selection of B lymphocytes in the germinal centre (GC). This study therefore investigated the expression o
Engulfment of prions in the germinal centre
โ Scribed by Alex J. Raeber; Adriano Aguzzi
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 147 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0167-5699
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Fas ligand (FasL), a cell surface molecule belonging to the tumour necrosis family, induces apoptosis through its receptor, Fas antigen (Fas). Germinal centre B cells strongly express Fas, but the role of the Fas-FasL system in B-cell selection in the germinal centre remains unclear. In the present
The humoral immune response constitutes an efficient system to protect the organism against diseases caused by invading pathogens. To guarantee a highly efficient defence, the humoral immune system has to be tightly regulated. Two cell subsets in particular, T cells and follicular dendritic cells (F