Engineering the mouse genome by site-specific recombination

✍ Scribed by Daniel Metzger; Robert Feil

• Book ID: 104362188
• Publisher: Elsevier Science
• Year: 1999
• Tongue: English
• Weight: 109 KB
• Volume: 10
• Category: Article
• ISSN: 0958-1669
• DOI: 10.1016/s0958-1669(99)00012-9

✦ Synopsis

Site-specific recombination systems are powerful tools for introducing predetermined modifications into eukaryotic genomes. Recent advances allow the manipulation of chromosomal DNA in a spatially and temporally controlled manner in mice, offering unprecedented possibilities for studying mammalian genome function and for generating animal models for human diseases.