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Engineering S-protein fragments of bovine ribonuclease A for targeted drug delivery

✍ Scribed by Marina V Backer; Timur I Gaynutdinov; Renee Aloise; Kristen Przekop; Joseph M Backer


Book ID
117702560
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
210 KB
Volume
26
Category
Article
ISSN
1046-5928

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## Abstract Mucopolysaccharidosis Type I, Hurler's Syndrome, is a lysosomal storage disorder that affects the brain. The missing enzyme, α‐L‐iduronidase (IDUA), does not cross the blood‐brain barrier (BBB). To enable BBB transport of the enzyme, human IDUA was fused to the carboxyl terminus of the